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fosinopril (Monopril)
Tradename: Monopril.
Indications:
- hypertension
- heart failure
- diabetic nephropathy
- nondiabetic proteinuric nephropathy
- scleroderma, scleroderma renal crisis
Dosage:
- HTN: start 10 mg PO QD, max 80 mg/day
- CHF: start 5-10 mg QD; max 40 mg QD
Tabs: 10, 20 mg.
Pharmacokinetics:
1) fosinopril is about 99% bound to plasma proteins
2) metabolized in the liver to an active metabolite
3) elimination 1/2life is about 12 hours with normal renal function
4) 50% of the drug is eliminated by the liver, 50% in the urine
5) no dosage adjustments needed in patients with renal insufficiency
Adverse effects:
1) dry, non-productive cough
2) rash
3) taste disturbances
4) worsening renal failure
5) angioedema (rare)
Drug interactions:
1) NSAIDs reduce may reduce hypotensive effect
2) phenothiazines increase effects of ACE inhibitors
3) allopurinol increases risk of hypersensitivity reactions
4) lithium & digoxin levels are increased by fosinopril
5) K+ salts & K+ sparing diuretics: increased risk of hyperkalemia
Mechanism of action:
- phosphorous-containing ACE inhibitor (prodrug)
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with ACE inhibitors
General
angiotensin-converting enzyme (ACE) inhibitor
Properties
INHIBITS: angiotensin converting enzyme
MISC-INFO: elimination route LIVER
KIDNEY
pregnancy-category D
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
Department of Veterans Affairs, VA National Formulary
- non formulary drug request
- Deprecated Reference
Component-of
fosinopril/hydrochlorothiazide