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fosfomycin (Monurol, Phosphonemycin)

Indications: - simple urinary tract infection (UTI), including UTI due to multidrug-resistant gram negative bacteria Contraindications: - pyelonephritis (inadequate renal tissue levels) [4] Dosage: 1) 3 g packet single oral dose, 2nd dose on day 5 for complicated UTI 2) 1-16 g/day IV (only available PO in U.S.) Antimicrobial activity: - gram-positive bacteria, including MRSA & VRE - gram-negative bacteria, including multidrug-resistant gram negative bacteria [3] Adverse effects: - gastrointestinal distress Notes: - less effective & more expensive than nitrofurantoin or TMP/SMX (Bactrim) [4]

Interactions

drug interactions

General

other antibiotic

Properties

MISC-INFO: elimination route KIDNEY pregnancy-category B safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. Reeves DS. Treatment of bacteriuria in pregnancy with single dose fosfomycin trometamol: a review. Infection. 1992;20 Suppl 4:S313-6. Review. PMID: 1294525
  2. Bayrak O, Cimentepe E, Inegol I, Atmaca AF, Duvan CI, Koc A, Turhan NO. Is single-dose fosfomycin trometamol a good alternative for asymptomatic bacteriuria in the second trimester of pregnancy? Int Urogynecol J Pelvic Floor Dysfunct. 2006 Aug 29; PMID: 16941068
  3. Medical Knowledge Self Assessment Program (MKSAP) 16, 18. American College of Physicians, Philadelphia 2012, 2018.
  4. NEJM Knowledge+ Question of the Week. Jan 30, 2018 https://knowledgeplus.nejm.org/question-of-week/1569/