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fosamprenavir (Lexiva)

Tradename: Lexiva Indications: -> HIV1 infection Monitor: - lipid panel prior to initiating fosamprenavir & periodically thereafter [4] Adverse effects: - nausea, diarrhea, rash [5] - increases in serum cholesterol have occurred with treatment - possible increased risk of myocardial infarction [2] Mechanism of action: -> prodrug of amprenavir

Interactions

drug interactions drug adverse effects (more general classes)

Related

amprenavir (Agenerase)

General

antiretroviral protease inhibitor

Properties

INHIBITS: protease

Database Correlations

PUBCHEM correlations

References

  1. Prescriber's Letter 11(2):suppl 2004
  2. FDA MedWatch Lexiva (fosamprenavir calcium) - Dear Healthcare Professional Letter http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm192699.htm
  3. Department of Veterans Affairs, VA National Formulary
  4. FDA Patient Safety News Cardiovascular Problems with Lexiva http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/psn/transcript.cfm?show=95#2
  5. Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015