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formiminoglutamicaciduria; glutamate formiminotransferase deficiency

Genetics: 1) autosomal recessive 2) associated with defects in FTCD gene Clinical manifestations: 1) in severe phenotype - megaloblastic anemia - mental retardation 2) in mild phenotype - mild developmental delay - no hematological abnormalities Laboratory: - elevated levels of formiminoglutamate in urine with or without administration of histidine, depending on phenotype

General

amino acid inborn error of metabolism

Database Correlations

OMIM 229100

References

OMIM :accession 229100