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folylpolyglutamate synthase, mitochondrial; folylpoly-gamma-glutamate synthetase; FPGS; tetrahydrofolylpolyglutamate synthase; tetrahydrofolate synthase (FPGS)
Function:
- conversion of folates to polyglutamate derivatives
- this allows tissues to concentrate folate at higher levels than in plasma
- cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate
ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1)
Structure:
- monomer
- belongs to the folylpolyglutamate synthase family
Compartment: mitochondria. cytoplasm
Alternative initiation: named isoforms=2
General
ligase or synthetase
Properties
SIZE: entity length = 587 aa
MW = 65 kD
COMPARTMENT: mitochondria
cytoplasm
MOTIF: Ser phosphorylation site {S33}
ATP-binding site
NAME: ATP-binding site
SITE: 103-109
Database Correlations
OMIM 136510
UniProt Q05932
Pfam PF02875
Entrez Gene 2356
Kegg hsa:2356
ENZYME 6.3.2.17
References
UniProt :accession Q05932