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follicle center lymphoma, grade III (follicular large cell lymphoma)
Intermediate-grade lymphoma.
Classification:
1) working formulation
-> follicular, predominantly large cell
2) Rappaport
-> nodular, histiocytic
3) Lukes-Collins
-> FCC*, large cleaved &/or non-cleaved
4) Kiel
-> centroblastic lymphoma, follicular
* FCC: follicular center cells
Epidemiology:
1) uncommon
2) < 15% of follicular lymphomas
Pathology:
1) neoplastic B-cells
2) large cells, with cleaved or non-cleaved nuclei
3) mitotic figures common
4) prone to develop into diffuse lymphoma early in their course
Management:
1) R-CHOP (rituximab, cyclophosphamaide, doxorubicin, vincristine & prednisone) induction [3]
2) maintenance for 2 years with rituximab [3]
3) hematopoietic stem cell transplantation may be appropriate for relapse [3]
3) prognosis poorer than with other follicular lymphomas
Interactions
disease interactions
Related
follicular center cell
General
follicular B-cell lymphoma; follicular center lymphoma; chronic lymphatic leukemia type 2
References
- Cotran et al Robbins Pathologic Basis of Disease,
W.B. Saunders Co, Philadelphia, PA 1989 pg 712-713
- Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML,
Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al.
A revised European-American classification of lymphoid
neoplasms: a proposal from the International Lymphoma Study
Group.
Blood. 1994 Sep 1;84(5):1361-92. Review.
PMID: 8068936
- Medical Knowledge Self Assessment Program (MKSAP) 16,
American College of Physicians, Philadelphia 2012