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follicle center lymphoma, grade II (follicular mixed small & large cell lymphoma)

Low-grade lymphoma. Classification: 1) working formulation -> follicular, mixed small cleaved cell & large cell 2) Rappaport -> nodular, mixed lymphocytic histiocytic 3) Lukes-Collins -> FCC*, small cleaved & large cleaved 4) Kiel -> centroblastic-centrocytic lymphoma, follicular * FCC: follicular center cells Epidemiology: -> small % of follicular lymphomas Pathology: 1) neoplastic B-cells 2) 20-50% of follicular cells (see follicular small cleaved cell lymphoma) are large cells 3) may not be distinct form 4) may be slightly more aggressive form of follicular small cleaved cell lymphoma Management: 1) see follicular center lymphoma 2) combination chemotherapy is controversial a) C-MOPP b) CHOP

Interactions

disease interactions

Related

cyclophosphamide/doxorubicin/vincristine (Oncocin)/prednisone (CHOP) cyclophosphamide/vincristine (Oncovin)/prednisone/procarbazine (C-MOPP) follicular center cell

General

follicular B-cell lymphoma; follicular center lymphoma; chronic lymphatic leukemia type 2

References

  1. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 712-713
  2. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994 Sep 1;84(5):1361-92. Review. PMID: 8068936
  3. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 700-704