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follicle center lymphoma, grade I (follicular small cleaved cell lymphoma)
Low-grade lymphoma.
Classification:
1) working formulation
-> follicular, predominantly small cleaved cell
2) Rappaport
-> nodular, poorly differentiated lymphocytic
3) Lukes-Collins
-> FCC*, small cleaved
4) Kiel
-> centroblastic-centrocytic lymphoma, follicular
* FCC: follicular center cells
Epidemiology:
-> most common form of follicular lymphoma
Pathology:
1) neoplastic B-cells
2) small, cleaved cells within normal germinal centers
3) slightly larger than normal lymphocytes
4) scantly cytoplasm
5) irregular, cleaved nuclear contour*
-> prominent clefts, indentations, linear infoldings
6) course & condensed nuclear chromatin
7) indistinct nucleoli
8) mitoses are infrequent
9) may be scattered large cleaved or non-cleaved cells within the nodule (< 20% of cells)
* distinguishing feature of neoplastic cells
Interactions
disease interactions
Related
follicular center cell
General
follicular B-cell lymphoma; follicular center lymphoma; chronic lymphatic leukemia type 2
References
- Cotran et al Robbins Pathologic Basis of Disease,
W.B. Saunders Co, Philadelphia, PA 1989 pg 712-713
- Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML,
Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al.
A revised European-American classification of lymphoid
neoplasms: a proposal from the International Lymphoma Study
Group.
Blood. 1994 Sep 1;84(5):1361-92. Review.
PMID: 8068936