folate antagonist; folic acid analog; folic acid antagonist

Uses: - cancer chemotherapy - antibiotic Mechanism of action: - inhibits of folate metabolism - inhibits dihydrofolate reductase

Specific

methotrexate (Rheumatrex, MTX) pemetrexed (Alimta, LY231514, Rolazar, Tifolar) trimethoprim; TMP (Proloprim, Trimpex)

General

antimetabolite enzyme inhibitor

References

- NLM MeSH Browser http://www.nlm.nih.gov/mesh/meshhome.html