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5-fluorouracil/oxaliplatin/leucovorin (FOLFOX)

Indications: - stage 3 node positive colorectal carcinoma Dosage: - 12 cycles, every 2 weeks - day 1: - oxaliplatin 85 mg/m2 IV infusion in 250-500 mL D5W - leucovorin 200 mg/m2 IV infusion in D5W over 2 hours at the same time (separate bags) - follow with 5-fluorouracil 400 mg/m2 IV bolus over 2-4 minutes, then 600 mg/m2 IV infusion in 500 mL D5W as a 22-hour continuous infusion - day 2: - no oxaliplatin - leucovorin & 5-fluorouracil as in day 1 Adverse effects: - 5-fluorouracil induced hyperpigmentation of palms [2] (image)

General

antineoplastic combination (combination chemotherapy)

References

  1. Haller DG et al Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer. J Clin Oncol. 2011 Apr 10;29(11):1465-71. PMID: 21383294
  2. Schaefer JK, Ramnath N Fluorouracil-Induced Hyperpigmentation N Engl J Med 2020; 382:e6. Jan 23 PMID: 31971682 https://www.nejm.org/doi/full/10.1056/NEJMicm1909329

Components

5-fluorouracil [5-FU] (Fluoroplex, Efudex, Adrucel, Carac) N5-formyltetrahydrofolate (folinic acid, citrovorum factor, Fusilev) oxaliplatin (Eloxatin)