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focused ultrasound
Indications:
- GSK-3 inhibitor delivery for amyloid-beta plaque reduction in patients with Alzheimer's disease
Mechanism of action:
- increases drug availability by making the blood-barrier more porous
- allows larger molecules to cross the blood-brain barrier
- activates microglia, thus lessening amyloid accumulation
General
ultrasound (US, UTZ)
drug delivery system
References
- Hsu PH, Lin T, Chung YH et al.
Focused ultrasound-induced blood-brain barrier opening enhances
GSK-3 inhibitor delivery for amyloid-beta plaque reduction.
Sci Rep 2018 Aug 27; 8:12882
PMID: 30150769 Free PMC Article
https://www.nature.com/articles/s41598-018-31071-8