Search
folliculin-interacting protein 1 (FNIP1, KIAA1961)
Function:
- may be involved in energy &/or nutrient sensing through the AMPK & mTOR signaling pathways
- interacts with the C-terminus of FLCN, with HSPCA & with the PRKAA1, PRKAB1 & PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK)
- phosphorylated FLCN & AMPK are preferentially bound
- phosphorylated by AMPK
Structure: belongs to the FNIP1 family
Compartment: cytoplasm
Alternative splicing: named isoforms=3
Expression:
- expressed in heart, liver & placenta > kidney & lung
General
phosphoprotein
Properties
SIZE: entity length = 1166 aa
MW = 131 kD
MOTIF: serine-rich region {96-99}
MOTIF: serine residue (SEVERAL)
Database Correlations
UniProt Q8TF40
References
- UniProt :accession Q8TF40
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/Genes/FNIP1ID44003ch5q23.html