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Fibronectin type 3 domain-containing protein 1 (expressed in synovial lining protein, activation-associated cDNA protein, FNDC1, FNDC2, KIAA1866, MEL4B3)
Function:
- activator of G protein signaling (putative)
Structure: contains 5 fibronectin F3 modues
Alternative splicing: named isoforms=4
Expression:
- isoform 4 is almost absent from healthy skin, barely detectable in benign melanocytic nevi
Pathology:
- induced by TGF-beta present in melanoma cell conditioned medium
- expressed in the stroma close to skin tumors, in the tumor cells themselves & in the epidermis of psoriasis
General
fibronectin type-3 domain-containing protein (FNDC)
Properties
SIZE: MW = 199 kD
entity length = 1836 aa
MOTIF: fibronectin type III domain or F3 module {2-77}
fibronectin type III domain or F3 module {106-198}
fibronectin type III domain or F3 module {207-302}
fibronectin type III domain or F3 module {307-401}
serine-rich region {619-721}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 954-957
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 1191-1196
MOTIF: proline residue (SEVERAL)
threonine-rich region {1391-1458}
MOTIF: threonine residue (SEVERAL)
fibronectin type III domain or F3 module {1597-1691}
Database Correlations
UniProt Q4ZHG4
Pfam PF00041
References
UniProt :accession Q4ZHG4