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flutamide (Eulexin, Niftholide)

Tradename: Eulexin. Indications: - used in combination with LHRH agonist for treatment of metastatic prostate cancer - hair growth restoration ? Contraindications: - Pregnancy category X - significant liver disease Dosage: Capsule: 125 mg Pharmacokinetics: - Not eliminated by hemodialysis Monitor: - serum ALT & serum AST baseline, monthly for 4 months, then periodically (every 6 months) [2,3]; discontinue if serum AST or serum ALT > 3x upper limit of normal despite recheck Adverse effects: 1) common (> 10%) - impotence, nausea/vomiting, hot flashes, diarrhea 2) less common (1-10%) - anorexia, gynecomastia, numbness in extremities 3) uncommon (< 1%) - hepatitis, hypertension, edema, drowsiness, nervousness, confusion Mechanism of action: - androgen receptor antagonist

Related

prostate cancer

General

androgen receptor antagonist; androgen receptor signaling inhibitor (ARSI) antineoplastic endocrine agent

Properties

INHIBITS: androgen receptor MISC-INFO: pregnancy-category X

Database Correlations

PUBCHEM cid=3397

References

  1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  2. deprecated reference
  3. Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: 260704 (subscription needed) http://www.prescribersletter.com
  4. PubMed Health: Flutamide http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001014/