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Fluocinolone Topical (Synalar, Synemol, Fluonid, Derma-Smoothe/FS, Synandrone)
Indications:
- relief of inflammatory dermatoses (dermatitis)
- allergic dermatitis
- atopic dermatitis, contact dermatitis [4]
- seborrheic dermatitis
- dandruff
- discoid lupus
- granuloma annulare
- psoriasis
- pruritus, anal pruritus
- lichen simplex chronicus
- alleriges
- cutaneous T-cell lymphoma [4]
Dosage: Topical: Apply BID/TID
Cream: 0.01%, 0.025%, 0.2%.
Ointment: 0.025%.
Solution: 0.01%.
Shampoo: 0.01%. Oil: (Derma-Smoothe/FS) 0.01% (120 mL)
Low potency (0.01%).
Occlusive dressings may be used for resistant or severe dermatoses
Adverse effects:
- uncommon (< 1%)
- burning, itching, skin irritation, dryness, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, secondary infection, skin atrophy, striae, miliaria, intracranial hypertension, hypothalamic-pituitary-adrenal axis suppression, Cushing's syndrome, growth retardation
Mechanism of action:
- anti-inflammatory; topical glucocorticoid class 4, class 5
Interactions
drug adverse effects of glucocorticoids
monitor with drug (more general terms)
General
fluocinolone acetonide
topical glucocorticoid (topical steroid)
Properties
MISC-INFO: pregnancy-category C
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015
- Department of Veterans Affairs, VA National Formulary