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fludrocortisone (Florinef)
Tradename Florinef.
Indications:
1) Addison's disease
2) replacement therapy for adrenal insufficiency
3) treatment of salt-losing forms of congenital adrenogenital syndrome
4) orthostatic hypotension
Adults 0.05-0.2 mg PO QD.
Infants & children: 0.05-0.1 PO QD
Tabs: 0.1 mg.
Adverse effects:
- most common (1-10%)
- hypertension, dizziness, edema, congestive heart failure, convulsions, headache, acne, rash, hypokalemic alkalosis, growth suppression, hyperglycemia, suppression of hypothalamic-pituitary-adrenal axis, peptic ulcer, bruising, muscle weakness, cataracts
Drug interactions:
1) aminoglutethimide
2) anticholinesterases
3) barbiturates
4) carbamazepine
5) phenytoin
6) rifampin
7) vaccines (live virus)
Laboratory:
- fludrocortisone in serum/plasma
- fludrocortisone in urine
Mechanism of action: pure mineralocorticoid.
Interactions
monitor with mineralocorticoids
Related
Addison's disease (primary adrenal failure)
orthostatic hypotension; Bradbury-Eggleston Syndrome; postural orthostatic tachycardia syndrome (POTS)
General
mineralocorticoid
Properties
MISC-INFO: elimination route LIVER
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998