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vascular endothelial growth factor receptor 3; VEGFR-3; tyrosine-protein kinase receptor FLT4 (FLT4)
Function:
- receptor for VEGFC
- has a tyrosine-protein kinase activity
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
- contains 7 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 protein kinase domain
Compartment: membrane
Expression:
- placenta, lung, heart, & kidney
- does not seem to be expressed in pancreas & brain
Pathology:
- defects in FLT4 are the cause of lymphedema hereditary type-1
- defects in FLT4 are found in juvenile hemangioma
General
vascular endothelial growth factor [VEGF] receptor
Properties
SIZE: entity length = 1298 aa
MW = 146 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-24}
immunoglobulin superfamily domain {30-127}
MOTIF: N-glycosylation site {N33}
cysteine residue {C51}
MODIFICATION: cysteine residue {C111}
N-glycosylation site {N104}
cysteine residue {C111}
MODIFICATION: cysteine residue {C51}
immunoglobulin superfamily domain {151-213}
MOTIF: cysteine residue {C158}
MODIFICATION: cysteine residue {C206}
N-glycosylation site {N166}
cysteine residue {C206}
MODIFICATION: cysteine residue {C158}
immunoglobulin superfamily domain {219-326}
MOTIF: N-glycosylation site {N251}
cysteine residue {C252}
MODIFICATION: cysteine residue {C310}
N-glycosylation site {N299}
cysteine residue {C310}
MODIFICATION: cysteine residue {C252}
immunoglobulin superfamily domain {331-415}
MOTIF: N-glycosylation site {N411}
immunoglobulin superfamily domain {422-552}
MOTIF: cysteine residue {C445}
MODIFICATION: cysteine residue {C534}
N-glycosylation site {N515}
N-glycosylation site {N527}
cysteine residue {C534}
MODIFICATION: cysteine residue {C445}
immunoglobulin superfamily domain {555-671}
MOTIF: cysteine residue {C578}
MODIFICATION: cysteine residue {C653}
N-glycosylation site {N594}
cysteine residue {C653}
MODIFICATION: cysteine residue {C578}
immunoglobulin superfamily domain {678-764}
MOTIF: N-glycosylation site {N683}
N-glycosylation site {N690}
cysteine residue {C699}
MODIFICATION: cysteine residue {C751}
cysteine residue {C751}
MODIFICATION: cysteine residue {C699}
N-glycosylation site {N758}
transmembrane domain {776-797}
kinase domain
SITE: 845-1173
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 851-859
ATP-binding site
NAME: ATP-binding site
SITE: 879-879
aspartate residue {D1037}
Tyr phosphorylation site {Y1063}
Tyr phosphorylation site {Y1068}
Database Correlations
OMIM correlations
MORBIDMAP 136352
UniProt P35916
PFAM correlations
KEGG correlations
ENZYME 2.7.10.1
References
- UniProt :accession P35916
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=FLT4