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FLT3 gene mutation
Clinical significance:
- somatic mutations leading to constitutive activation of FLT3 are a cause of acute myeloid leukemia (AML)
- mutations fall into two classes
- the most common is in-frame internal tandem duplications of variable length in the juxtamembrane region that disrupt the normal regulation of kinase activity
- point mutations in the kinase domain can result in a constitutively activated kinase
Related
FL cytokine receptor; tyrosine-protein kinase receptor FLT3; stem cell tyrosine kinase 1; STK-1; CD135 (FLT3, STK1)
General
gene mutation testing; gene mutation analysis
References
Loinc