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flotillin-1 (FLOT1)
Integral/structural component of lipid rafts.
Function:
- may act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles
- heterooligomeric complex of flotillin-1 & flotillin-2 & caveolin-1 & caveolin-2 (putative)
Structure:
- belongs to the band 7/mec-2 family, Flotillin subfamily
Compartment:
- cell membrane; peripheral membrane protein
- membrane, caveola; peripheral membrane protein
- melanosome
- membrane-associated protein of caveolae
- identified by mass spectrometry in melanosome fractions from stage I to stage IV
General
flotillin
phosphoprotein
Properties
SIZE: entity length = 427 aa
MW = 47 kD
COMPARTMENT: plasma membrane
MOTIF: Ser phosphorylation site {S19}
Tyr phosphorylation site {Y203}
Ser phosphorylation site {S385}
Thr phosphorylation site {T387}
Database Correlations
OMIM 606998
UniProt O75955
Pfam PF01145
Entrez Gene 10211
Kegg hsa:10211
References
- UniProt :accession O75955
- Galbiati et al,
Emerging themes in lipid rafts and caveolae.
Cell 106:403, 2001
PMID: 11525727