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prostaglandin I (prostacyclin, epoprostenol {Flolan})
[For molecular structure, see specific subtype in arachidonate, eicosapentaenoate, or eicosatrienoate cascade.]
Pharmacology:
Indications:
1) IV infusion for pulmonary hypertension
2) treatment of digital ischemia associated with severe Raynaud's disease
Mechanism of action:
1) produced by cyclooxygenase-2 in vascular endothelium
2) vasodilator
3) inhibits platelet aggregation
Related
cyclooxygenase cascade
prostacyclin receptor; prostanoid IP receptor; PGI receptor; prostaglandin I2 receptor (PTGIR, PRIPR)
Specific
prostaglandin I2
prostaglandin I3
treprostinil (Tyvaso, Unipros, Remodulin, Senicopac, Orenitram)
General
prostaglandin
Properties
COMPARTMENT: membrane
MISC-INFO: elimination route PLASMA
pregnancy-category B
safety in lactation ?
References
- Stedman's Medical Dictionary 27th ed, Williams &
Wilkins, Baltimore, 1999
- Prescriber's Letter 9(5):25-26 2002
- Journal Watch 22(10):78, 2002
Cheng Y et al
Role of prostacyclin in the cardiovascular response to
thromboxane A2.
Science 296:539, 2002
PMID: 11964481
- Vane JR
Biomedicine. Back to an aspirin a day?
Science 296:474, 2002
PMID: 11964462