Search
Friend leukemia integration 1 transcription factor; Fli-1 proto-oncogene protein; ERGB transcription factor (FLI1)
Function:
- sequence-specific transcriptional activator
- recognizes DNA sequence 5'-C[CA]GGAAGT-3'
- can form homodimers or heterodimers with ETV6/TEL1
Structure:
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
- contains 1 PNT (pointed) domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Pathology:
- chromosomal translocation t(11;22)(q24;q12) involving FLI1 with EWS is a cause of Ewing sarcoma; translocation results in fusion protein FLI1-EWS
- located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia- associated t(4;11)(q21;q23) translocation breakpoint & on the telomeric side by the Ewing- & neuroepithelioma-associated t(11;22) (q24;q12) breakpoint
General
Ets family protein
phosphoprotein
Properties
SIZE: entity length = 452 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S76}
Ser phosphorylation site {S86}
Ser phosphorylation site {S89}
PNT {114-198}
ETS domain
NAME: ETS domain
SITE: 281-361
Database Correlations
OMIM correlations
UniProt Q01543
PFAM correlations
Entrez Gene 2313
Kegg hsa:2313
References
- Macleod K, Leprince D, Stehelin D.
The ets gene family.
Trends Biochem Sci. 1992 Jul;17(7):251-6. Review.
PMID: 1502727
- Entrez Gene :accession 2313
- UniProt :accession Q01543