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sodium biphosphate (Fleet phospho soda enema)

Tradename: Fleet enema. NaH2PO4 Indications: 1) relief of constipation 2) phosphate replacement Dosage: 1) enema a) one bottle (4.5 oz, 118 mL) once, may repeat twice b) 1/2 dose if child > 2 yo 2) phosphate replacement: a) 5-10 mL (0.9 g/5 mL) PO BID/TID b) maximum dose: 45 mL/24 hours [4] Bottles: 4.5 oz, 118 mL containing 26 g of phosphate & 4.4 g of sodium Pharmacokinetics: 1) onset of bowel relief is in 2-15 minutes or 1-2 hours 2) elimination: enema not absorbed Adverse effects: 1) hyperphosphatemia resulting from excessive PO intake - phosphate nephropathy [5,6] 2) electrolyte imbalances [4] 3) dehydration [4] 4) renal failure [4] Mechanism of action: saline laxative

Related

fleets enema

General

laxative

Properties

MISC-INFO: elimination route FECES pregnancy-category + safety in lactation ?

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Prescriber's Letter 8(12):69 2001
  5. FDA Web site (http://www.fda.gov/medwatch/safety/2006/safety06.htm#phosphate
  6. Prescriber's Letter 13(5): 2006 Acute Phosphate Nephropathy and Renal Failure Associated with the Use of Oral Sodium Phosphate Bowel Cleansing Products Detail-Document#: 220614 (subscription needed) http://www.prescribersletter.com

Component-of

sodium biphosphate/sodium phosphate