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CASP8-associated protein 2 (FLICE-associated huge protein, CASP8AP2, FLASH, KIAA1315, RIP25)
Function:
- role in TNF-alpha-induced blockade of glucocorticoid receptor transactivation at the nuclear receptor coactivator level, upstream & independently of NF-kappa-B
- suppresses both NCOA2- & NCOA3-induced enhancement of glucocorticoid receptor transactivation
- role in TNF-alpha-induced activation of NF-kappa-B (TRAF2- dependent)
- role as downstream mediator for CASP8-induced activation of NF-kappa-B
- required for activation of CASP8 in FAS-mediated apoptosis
- self-associates
- component of the death-inducing signaling complex
- interacts with NCOA2, NCOA3 & TRAF2
Compartment: cytoplasm, nucleus.
Expression:
- induced by TNF-alpha, which induces nuclear localization
General
other protein
Properties
SIZE: MW = 223 kD
entity length = 1982 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: binding site
SITE: 1709-1982
FOR-BINDING-OF: nuclear receptor coactivator 2
Database Correlations
OMIM 606880
UniProt Q9UKL3
References
- UniProt :accession Q9UKL3
- Hersey & Zhang. Nature Reviews Cancer 1:142-50, 2001
- Imai et al. Nature 398:777-785, 1999
Component-of
death-inducing signaling complex (DISC)