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FK506-binding protein 1B (12.6 kD FK506-binding protein, immunophilin FKBP12.6, FKBP1B)
Function:
- negative regulator of ryanodine receptor Ca2+ release
- interacts directly with RYR2
- may contribute to the immunosuppressive & toxic effects of FK506 & rapamycin
- rotamases accelerate the folding of proteins
- catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
- inhibited by both FK506 & rapamycin
- component of AKAP6/FKBP1B/PKA catalytic/PP1/PP2A/PRKAR2A/RYR2 complex
Structure:
- belongs to the FKBP-type PPIase family, FKBP1 subfamily
Compartment:
- cytoplasm . sarcoplasmic reticulum
Alternative splicing: named isoforms=2
Expression:
- detected in heart muscle (at protein level)
- isoform 1 & isoform 2 are ubiquitous with highest levels in brain & thymus
Comparative biology:
- overexpression of FKBP1b in hippocampus of rats reverses age- associateed memory impairment & neuronal Ca+2 dysregulation [1]
General
FK506 binding protein (FKBP)
Properties
SIZE: MW = 12 kD
entity length = 107 aa
COMPARTMENT: cytoplasm
MOTIF: active site
SITE: 19-107
Database Correlations
OMIM 600620
UniProt P68106
Pfam PF00254
Entrez Gene 2281
Kegg hsa:2281
ENZYME 5.2.1.8
References
- UniProt :accession P68106
- Gant JC, Blalock EM, Chen KC et al
FK506-Binding Protein 12.6/1b, a negative regulator of [Ca2+],
rescues memory and restores genomic regulation in the
hippocampus of aging rats.
J Neurosci. 2017 Dec 18, 2234-17
PMID: 29255009
http://www.jneurosci.org/content/early/2017/12/18/JNEUROSCI.2234-17.2017
Component-of
AKAP6/FKBP1B/PKA catalytic/PP1/PP2A/PRKAR2A/RYR2