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fibronectin type III domain or F3 module
One of 3 types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type 3 repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including:
- extracellular & intracellular proteins
- membrane spanning cytokine receptors
- growth hormone receptors
- tyrosine phosphatase receptors
- adhesion molecules
- other proteins
FN3-like domains are also found in bacterial glycosyl hydrolases.
Three F3 modules form heparan sulfate-binding domain of fibronectin. However, Fibronectin has 15-17 such domains distributed in 3 molecular regions, the majority of which do not appear essential for heparan sulfate binding. The F3 module is absent from fibronectin secreted by hepatocytes.
General
fibronectin module
References
- Baron M, Norman DG, Campbell ID.
Protein modules.
Trends Biochem Sci. 1991 Jan;16(1):13-7. Review.
PMID: 2053133
- Ohashi T et al,
Dynamics and elasticity of the fibronnectin matrix in living
cell culture visualized by fibronectin-green fluorescent
protein.
Proc Natl Acad Sci USA 1999, 96:2153
PMID: 10051610
- Conserved Domains Database, NCBI
http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?