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fibrodysplasia ossificans progressiva

Epidemiology: rare Genetics: - autosomal dominant - associated with defects in ACVR1 Clinical manifestations: - skeletal malformations - progressive extraskeletal ossification a) begins in childhood b) can be induced by trauma c) may occur without warning - bone formation is episodic & progressive, leading to extra-articular ankylosis of all major joints of the axial & appendicular skeleton, rendering movement impossible

General

myositis ossificans

Database Correlations

OMIM 135100

References

  1. OMIM :accession 135100
  2. Pignolo r AND Jung lk eMedicine: Pediatric Fibrodysplasia Ossificans Progressiva (Myositis Ossificans). http://emedicine.medscape.com/article/1007104-overview