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fibroblast
Fibroblasts from papllary dermis & reticular dermis are different [1]
Histology:
- papillary fibroblasts appear lean & spindle-shaped in culture
- reticular fibroblasts appear more square & stretched and also express more alpha-smooth muscle actin
Pathology:
- it has been proposed that skin aging is caused by the loss of papillary fibroblasts (see skin aging)
Genetics:
- reticular fibroblasts were more prone to overexpress genes in pathways controlling smooth muscle contraction, cytoskeletal organization, cell motility, & neuronal development
- matrix Gla protein is almost exclusively expressed in the reticular dermis
- papillary fibroblasts were more prone to overexpress genes related to complement activation, host defense, & immune response
Related
beta-N-acetylhexosaminidase A in fibroblasts
beta-N-acetylhexosaminidase B in fibroblasts
beta-N-acetylhexosaminidase in fibroblasts
Specific
3T3 cell
CHW cell
L cell
myofibroblast (myofibrocyte)
General
connective tissue cell
References
- Janson DG et al.
Different gene expression patterns in human papillary and
reticular fibroblasts.
J Invest Dermatol 2012 Nov; 132:2565
PMID: 22696053