fibroblast growth factor receptor substrate 2; FGFR substrate 2; Suc1-associated neurotrophic factor target 1; SNT-1; FGFR signalling adaptor SNT (FRS2)

Function: 1) adapter protein that links FGR & NGF receptors to downstream signaling pathways 2) activation of MAP kinases & in phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1 3) modulates signaling via SHC1 by competing for a common binding site on NTRK1 4) component of complex containing FRS2, GRB2, SOS1 5) component of complex containing GRB2, CBL 6) binds RET, FGFR1, SUC1, NTRK1, NTRK2, NTRK3 & SRC 7) Tyr-phosphorylated protein binds the SH2 domains of GRB2 & PTPN11 8) phosphorylation - phosphorylated on Tyr upon stimulation by NGF - phosphorylated by ULK2 in vitro - phosphorylated on Tyr by activated ALK & FGFR1 - phosphorylated on Tyr upon activation of FGFR2 & FGFR3 - phosphorylation on Thr by MAP kinases inhibits Tyr phosphorylation, & down-regulates FRS2-mediated activation of MAP kinases 9) ubiquitinated when Tyr phosphorylated & in a complex with GRB2; unphosphorylated form is not subject to ubiquitination 10) component of various complexes - component of a complex containing FRS2, GRB2, GAB1, PIK3R1 & SOS1. - componentof a complex containing GRB2 & CBL - component of a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 & CTTN 11) binds RET (putative) 12) binds ALK, FGFR1, CKS2, MAPK1/ERK2, MAPK3/ERK1 & SRC 13) Tyr-phosphorylated FRS2 binds the SH2 domains of GRB2 & PTPN11 14) interacts with NTRK1, NTRK2 & NTRK3 (phosphorylated upon ligand-binding) Structure: contains 1 IRS-type PTB domain Compartment: cytoplasmic, membrane-bound Expression: - highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney, testis

Related

fibroblast growth factor fibroblast growth factor receptor substrate fibroblast growth factor [FGF] receptor

General

myristoylated protein phosphoprotein

Properties

SIZE: MW = 57 kD entity length = 511 aa COMPARTMENT: cytoplasm MOTIF: myristoylation site SITE: N-TERMINUS EFFECTOR-BOUND: myristate myristoylation site SITE: G2 EFFECTOR-BOUND: myristate phosphotyrosine interaction domain NAME: phosphotyrosine interaction domain SITE: 13-115 Ser phosphorylation site {S177} Tyr phosphorylation site {Y196} Ser phosphorylation site {S211} Ser phosphorylation site {S221} Tyr phosphorylation site {Y306} Tyr phosphorylation site {Y349} Tyr phosphorylation site {Y392} Tyr phosphorylation site {Y436} Tyr phosphorylation site {Y471}

Database Correlations

OMIM 607743 UniProt Q8WU20 Pfam PF02174 Entrez Gene 10818 Kegg hsa:10818

References

UniProt :accession Q8WU20