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fibrillarin (U3 RNP) IgG in serum

Epidemiology: - more common in black men [1] Pinciple: - anti-fibrillarin Ab Clinical significance: - associated with poor outcomes in scleroderma a) scleroderma complicated by pulmonary hypertension b) diffuse cutaneous scleroderma c) scleroderma complicated by myositis - speckled antinuclear antibody pattern

Related

U3-snRNP; U3 small nuclear ribonucleoprotein

General

fibrillarin (U3 RNP) Ab in serum

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 16, 17 American College of Physicians, Philadelphia 2012, 2015