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fibroblast growth factor

family of growth factors, 22 members in humans Function: - roles in angiogenesis, wound healing, & embryonic development - secretion by endothelial cells may require cell injury - heparin-binding proteins - affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors - members FGF1 - FGF10 all bind FGF receptors - members FGF11-23 may not bind FGF receptors Structure: - precursors to acidic & basic FGF do not contain ER signal sequences Compartment: secreted Comparative biology: - FGF15 is the mouse ortholog of human FGF19 (thus there is no human FGF15)

Interactions

molecular events

Related

fibroblast growth factor [FGF] receptor

Specific

fibroblast growth factor 10; FGF-10; keratinocyte growth factor 2 (FGF10) fibroblast growth factor 11; FGF-11; fibroblast growth factor homologous factor 3; FHF-3 (FGF11, FHF3) fibroblast growth factor 12; FGF-12; fibroblast growth factor homologous factor 1; FHF-1; myocyte-activating factor (FGF12, FGF12B, FHF1) fibroblast growth factor 13; FGF-13; fibroblast growth factor homologous factor 2; FHF-2 (FGF13 FHF2) fibroblast growth factor 14; FGF-14; fibroblast growth factor homologous factor 4; FHF-4 (FGF14 FHF4) fibroblast growth factor 16; FGF-16 (FGF16) fibroblast growth factor 17; FGF-17 (FGF17) fibroblast growth factor 18; FGF-18; zFGF5 (FGF18) fibroblast growth factor 19; FGF-19 (FGF19, FGF15) fibroblast growth factor 1; FGF-1; acidic fibroblast growth factor; aFGF; endothelial cell growth factor; ECGF; heparin-binding growth factor 1; HBGF-1 (FGF1, FGFA) fibroblast growth factor 20; FGF-20 (FGF20) fibroblast growth factor 21; FGF-21 (FGF21) fibroblast growth factor 22; FGF-22 (FGF22) fibroblast growth factor 23; FGF-23; phosphatonin; tumor-derived hypophosphatemia-inducing factor; contains: fibroblast growth factor 23 N-terminal peptide; fibroblast growth factor 23 C-terminal peptide (FGF23, HYPF, UNQ3027/PRO9828) fibroblast growth factor 2; FGF-2; basic fibroblast growth factor; bFGF; heparin-binding growth factor 2; HBGF-2; prostatropin (FGF2, FGFB) fibroblast growth factor 3; FGF-3; heparin-binding growth factor 3; HBGF-3; proto-oncogene protein int-2 (FGF3, INT2) fibroblast growth factor 4; FGF-4; heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; heparin-binding growth factor 4; HBGF-4; transforming protein KS3 (FGF4, HST, HSTF1, KS3) fibroblast growth factor 5; FGF-5; heparin-binding growth factor 5; HBGF-5; smag-82 (FGF5) fibroblast growth factor 6; FGF-6; heparin secretory-transforming protein 2; HST-2; HSTF-2; heparin-binding growth factor 6; HBGF-6 (FGF6, HST2, HSTF2) fibroblast growth factor 7; FGF-7; heparin-binding growth factor 7; HBGF-7; keratinocyte growth factor (FGF7 KGF) fibroblast growth factor 8; FGF-8; androgen-induced growth factor; AIGF; heparin-binding growth factor 8; HBGF-8 (FGF8, AIGF) fibroblast growth factor 9; FGF-9; Glia-activating factor; GAF; heparin-binding growth factor 9; HBGF-9 (FGF9)

General

cytokine

Properties

SIZE: MW = 16-17 kD COMPARTMENT: extracellular compartment MOTIF: binding site FOR-BINDING-OF: heparan sulfate SECRETED-BY: endothelial cell

References

  1. Wikipedia: Fibroblast growth factor http://en.wikipedia.org/wiki/Fibroblast_growth_factor
  2. Hajjar DP & Pomerantz KB Signal transduction in atherosclerosis: integration of cytokines and the eicosanoid network. FASEB J 6:2933 1992 PMID: 1644257 (secretion)