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fibroblast growth factor receptor 4; FGFR-4; CD334 (FGFR4, JTK2, TKF)
Function:
- receptor for acidic fibroblast growth factor
- does not bind to basic fibroblast growth factor
- binds FGF19
- interacts with KLB (putative)
- phosphorylated on Tyr
- phosphorylation requires presence of a functional (phosphorylated) FGFR1 & not necessarily by means of FGFR heterodimerization (putative)
Structure:
- glycosylated (putative)
- belongs to the protein kinase superfamily, Tyr protein kinase family, fibroblast growth factor receptor subfamily
- contains 3 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 protein kinase domain
Compartment:
- membrane
- isoform 2 may be secreted
Alternative splicing: named isoforms=2
Expression:
- expressed in gastrointestinal epithelial cells, pancreas, & gastric & pancreatic cancer cell lines
- found in fetal adrenal gland
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
fibroblast growth factor [FGF] receptor
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 802 aa
MW = 88 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {22-118}
MOTIF: cysteine residue {C57}
MODIFICATION: cysteine residue {C101}
cysteine residue {C101}
MODIFICATION: cysteine residue {C57}
N-glycosylation site {N112}
immunoglobulin superfamily domain {152-240}
MOTIF: cysteine residue {C172}
MODIFICATION: cysteine residue {C224}
cysteine residue {C224}
MODIFICATION: cysteine residue {C172}
immunoglobulin superfamily domain {249-349}
MOTIF: N-glycosylation site {N258}
cysteine residue {C271}
MODIFICATION: cysteine residue {C333}
N-glycosylation site {N290}
N-glycosylation site {N311}
N-glycosylation site {N322}
cysteine residue {C333}
MODIFICATION: cysteine residue {C271}
transmembrane domain {370-390}
kinase domain
SITE: 467-755
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 473-481
ATP-binding site
NAME: ATP-binding site
SITE: 503-503
aspartate residue {D612}
Tyr phosphorylation site {Y643}
Database Correlations
OMIM 134935
MORBIDMAP 134935
UniProt P22455
PFAM correlations
Entrez Gene 2264
Kegg hsa:2264
ENZYME correlations
References
- UniProt :accession P22455
- NIEHS SNPs
http://egp.gs.washington.edu/data/fgfr4/
- Cross M, Dexter TM.
Growth factors in development, transformation, and tumorigenesis.
Cell. 1991 Jan 25;64(2):271-80. Review.
PMID: 1988148
- Partanen J et al
FGFR-4, a novel acidic fibroblast growth factor receptor with
a distinct expression pattern.
EMBO J. 1991 Jun;10(6):1347-54.
PMID: 1709094