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FGFR1 oncogene partenr (FGFR1OP, FOP)
Function:
1) anchoring microtubules to the centrosomes
2) ternary complex that contains CEP350, FGFR1OP, MAPRE1
3) interacts directly with CEP350, MAPRE1
Structure:
1) homodimer
2) contains 1 LisH domain
Compartment: centrosome, associated with gamma-tubulin
Alternative splicing: named isoforms=3
Expression:
- ubiquitous
- expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, pancreas
Pathology:
- chromosomal translocation t(6;8)(q27;p11) with FGFR1 may be a cause of stem cell myeloproliferative disorder
General
phosphoprotein
Properties
SIZE: MW = 43 kD
entity length = 399 aa
MOTIF: LisH {70-102}
Ser phosphorylation site {S156}
Ser phosphorylation site {S160}
breakpoint {173-174}
Database Correlations
OMIM 605392
UniProt O95684
References
- UniProt :accession O95684
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/FOPID140.html