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fexinidazole
Indications:
- treatment of both 1st-stage (hemolymphatic) & 2nd-stage (meningoencephalitic) African trypanosomiasis due to Trypanosoma brucei gambiense
Contraindications:
- < 6 years oof age or < 20 kg
- hepatic impairment
- severe renal impairment
* Trypanosoma brucei gambiense is a risk to mother & infant
* insufficient data on fexinidazole use in pregnant women
Dosage:
- > 35 kg: 1800 mg for 4 days then 1200 mg for 6 days
- 20-35 kg: 1200 mg for 4 days then 600 mg for 6 days
Tabs: 600 mg
Adverse effects:
- > 10%: headache, nausea/vomiting, insomnia, asthenia, tremor, decreased appetite, dizziness, dyspepsia, back pain, upper abdominal pain,
- hypocalcemia, hyperkalemia, neutropenia
- neuropsychiatric manifestations:
- agitation,anxiety, behavioral disturbance, depression, suicidal ideation, nightmares, hallucination, personality change
- precautions
- QTc prolongation
- hepatotoxicity
Mechanism of action:
- precise mechanism of action is unknown
General
nitroimidazole
antiprotozoal agent
References
- Highlights of prescribing information
FEXINIDAZOLE tablets, for oral use
https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214429s000lbl.pdf