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ferrous sulfate (FeSO4, Feosol)

Indications: prevention & treatment of iron deficiency. Contraindications: hemolytic anemia pregnancy category: + safety in lactation: + Dosage: - 250-325 mg PO QD {TID dosing excessive [3]} Tabs: 250, 300, 325 mg. (325 mg = 120 mg of elemental iron) Elixir: (Feosol) 220 mg/5 mL. 5-10 mL TID Pharmacokinetics: 1) absorbed in the duodenum & upper jejunum a) absorptive capacity limited b) NO benefit to > 325 mg QD [3,4] c) NO benefit to > 15 mg (elemental iron) QD in elderly [5] d) gastric acidity facilitates absorption 2) bound to serum transferrin 3) excreted in the urine 4) hemoglobin values response (increase) within 2-4 weeks Adverse effects: 1) GI irritation (dyspepsia) 2) nausea/vomiting 3) dark stool 4) constipation* (especially with doses > 325 mg QD) 5) diarrhea * constipation much more common than diarrhea Drug interactions: 1) FeSO4 may decrease absorption of tetracyclines 2) antacids & milk may decrease aborption of FeSO4

Related

Fe+2 (ferrous ion)

General

salt iron supplement

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Geriatrics Review Syllabus, American Geriatrics Society, 5th edition, 2002-2004
  4. Fick DM et al, Updating the Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, Arch Intern Med 163:2716, 2003 PMID: 14662625
  5. Kagansky RE et al Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. Am J Med 118(10):1142, 2005 PMID: 16194646

Component-of

ascorbate/cholecalciferol/ferrous sulfate/sodium fluoride/vitamin a ascorbate/ferrous sulfate ascorbate/ferrous sulfate/folic acid ascorbate/ferrous sulfate/nicotinic acid/pyridoxine/riboflavin/thiamine/vitamin a/vitamin d/vitamin e ascorbate/ferrous sulfate/vitamin A ascorbate/ferrous sulfate/vitamin A/vitamin D ferrous sulfate/folic acid