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protein fem-1 homolog A (FEM1-alpha, FEM1a, prostaglandin E receptor 4-associated protein, FEM1A, EPRAP)
Function:
- probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit
- may participate in antiinflammatory signaling via its interaction with PTGER4
- component of some E3 ubiquitin-protein ligase complex
- interacts with PTGER4
- protein degradation; protein ubiquitination
Structure:
- belongs to the fem-1 family
- contains 9 ANK repeats
- contains 2 TPR repeats
Compartment: cytoplasm (probable)
Expression:
- present in macrophages derived from peripheral blood monocytes
Pathology:
- present in atheromata (at protein level)
- frequently down-regulated in rhabdomyosarcoma
General
ankyrin repeat domain protein (ANKRD)
Properties
SIZE: entity length = 669 aa
MW = 74 kD
COMPARTMENT: cytoplasm
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 2-31
ankyrin repeat
NAME: ankyrin repeat
SITE: 40-70
ankyrin repeat
NAME: ankyrin repeat
SITE: 82-111
ankyrin repeat
NAME: ankyrin repeat
SITE: 115-145
ankyrin repeat
NAME: ankyrin repeat
SITE: 149-178
ankyrin repeat
NAME: ankyrin repeat
SITE: 182-211
ankyrin repeat
NAME: ankyrin repeat
SITE: 214-243
tetratricopeptide repeat {298-332}
tetratricopeptide repeat {390-423}
ankyrin repeat
NAME: ankyrin repeat
SITE: 534-576
ankyrin repeat
NAME: ankyrin repeat
SITE: 580-609
Database Correlations
UniProt Q9BSK4
Pfam PF00023
Kegg hsa:5552
References
UniProt :accession Q9BSK4