stabilin 2; FEEL-2 protein; fasciclin EGF-like, laminin-type E-like & link domain-containing scavenger receptor 1; FAS1; EGF-like & X-link domain containing adhesion molecule 2; hyaluronan receptor for endocytosis (STAB2, FEEL2, FEL,L FEX2, HARE)

Function: 1) binds to & mediates endocytosis of hyaluronic acid (hyaluronan receptor) 2) maintenance of tissue integrity by supporting extracellular matrix turnover 3) maintenance of fluidity of body fluids by resorption of hyaluronan 4) binds to both Gram-positive & Gram-negative bacteria - may play a role in defense against bacterial infection 5) proteolytically processed to yield a 190 kD protein Structure: - contains 17 EGF-like domains - contains 7 FAS1 domains - contains 2 laminin EGF-like domains - contains 1 link domain Compartment: plasma membrane Expression: - expressed in sinusoidal endothelial cells of liver, spleen, lymph nodes

General

glycoprotein scavenger receptor

Properties

SIZE: MW = 277 kD entity length = 2551 aa COMPARTMENT: plasma membrane MOTIF: EGF domain {108-362} (5) MOTIF: N-glycosylation site {N133} S1 domain {371-652} (2) MOTIF: N-glycosylation site {N619} N-glycosylation site {N720} EGF domain {736-992} (5) MOTIF: N-glycosylation site {N761} S1 domain {994-1265} (2) MOTIF: N-glycosylation site {N1016} N-glycosylation site {N1100} N-glycosylation site {N1275} EGF domain {1343-1594} (5) MOTIF: N-glycosylation site {N1437} N-glycosylation site {N1465} S1 domain {1596-1881} (2) MOTIF: N-glycosylation site {N1679} EGF domain {1957-2022} (4) MOTIF: N-glycosylation site {2165} LINK {2198-2291} MOTIF: N-glycosylation site {N2280} N-glycosylation site {N2296} S1 domain {2311-2446} MOTIF: N-glycosylation site {N2336} N-glycosylation site {N2393} transmembrane domain {2459-2479}

Database Correlations

OMIM 608561 UniProt Q8WWQ8 PFAM correlations Kegg hsa:5557

References

UniProt :accession Q9NY15