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ficolin-3; collagen/fibrinogen domain-containing lectin 3 p35; collagen/fibrinogen domain-containing protein 3; Hakata antigen (FCN3, FCNH, HAKA1)
Function:
- may function in innate immunity through activation of the lectin complement pathway
- Ca+2-dependent & GlcNAc-binding lectin
- has affinity with galNAc, GlcNAc, D-fucose, as mono/oligosaccharide & lipopolysaccharides from S typhimurium & S minnesota
- interacts with MASP1 & MASP2
- does not interact with fibronectin, elastin or zymosan
Structure:
- the N-terminus is blocked
- homopolymer; disulfide-linked
- may be an octadecamer consisting of an elementary trimer unit
- belongs to the ficolin lectin family
- contains 1 collagen-like domain
- contains 1 fibrinogen C-terminal domain
Compartment:
- secreted
- found in blood plasma, bronchus, alveolus & bile duct
Alternative splicing: named isoforms=2
Expression:
- expressed in liver & lung
- in liver it is produced by bile duct epithelial cells & hepatocytes
- in lung it is produced by both
- ciliated bronchial epithelial cells
- type II alveolar epithelial cells
Pathology:
- defects in FCN3 are the cause of ficolin 3 deficiency
General
ficolin
Properties
SIZE: entity length = 299 aa
MW = 33 kD
MOTIF: signal sequence {1-23}
Collagen-like {48-80}
Fibrinogen C-terminal {84-299}
MOTIF: N-glycosylation site {N189}
Database Correlations
OMIM correlations
MORBIDMAP 604973
UniProt O75636
PFAM correlations
Entrez Gene 8547
Kegg hsa:8547
References
- UniProt :accession O75636
- SeattleSNPs
http://pga.gs.washington.edu/data/fcn3/