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ficolin-2; 37 kD elastin-binding protein; collagen/fibrinogen domain-containing protein 2; EBP-37; Ficolin-B; Ficolin-beta; Hucolin; L-ficolin; serum lectin p35 (FCN2 FCNL)
Function:
- may function in innate immunity through activation of the lectin complement pathway
- Ca+2-dependent & GlcNAc-binding lectin
- enhances phagocytosis of S typhimurium by neutrophils, suggesting an opsonic effect via the collagen region
- interacts with elastin
- interacts with MASP1 & MASP2
Structure:
- homopolymer; disulfide-linked
- the fibrinogen-like domain (FBG) contains potential Ca+2-binding sites that may be involved in carbohydrate binding
- belongs to the ficolin lectin family
- contains 1 collagen-like domain
- contains 1 fibrinogen C-terminal domain
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed by the liver & secreted into plasma
General
ficolin
Properties
SIZE: entity length = 313 aa
MW = 34 kD
MOTIF: signal sequence {1-25}
Collagen-like {51-92}
Fibrinogen C-terminal {96-313}
MOTIF: N-glycosylation site {N240}
N-glycosylation site {N300}
Database Correlations
OMIM 601624
UniProt Q15485
PFAM correlations
Entrez Gene 2220
Kegg hsa:2220
References
UniProt :accession Q15485