F-box/WD repeat-containing protein 7; F-box & WD-40 domain-containing protein 7; F-box protein FBX30; Archipelago homolog; hAgo; SEL-10; hCdc4 (FBXW7, FBW7, FBX30, SEL10)

Function: - substrate recognition component of a SCF complex - probably recognizes & binds to phosphorylated target proteins - involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), & probably PSEN1 - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD & SKP1A Structure: - contains 1 F-box domain - contains 7 WD repeats Compartment: nucleus (putative) Alternative splicing: named isoforms=4 Expression: - isoform 1 is widely expressed - isoform 4 is expressed in brain

General

F-box & WD-repeat protein phosphoprotein

Properties

SIZE: entity length = 707 aa MW = 80 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S26} F-box domain {278-324} WD repeat {378-418} WD repeat {420-456} WD repeat {459-498} WD repeat {500-536} WD repeat {539-578} WD repeat {580-618} WD repeat {622-659}

Database Correlations

OMIM 606278 UniProt Q969H0 PFAM correlations Entrez Gene 55294 Kegg hsa:55294

References

UniProt :accession Q969H0