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F-box only protein 7 (FBXO7, FBX7)
Function:
- substrate recognition component of SCF complex
- BIRC2 & DLGAP5 protein modification; protein ubiquitination
- interacts via its C-terminal proline-rich region with DLGAP5
- interacts with BIRC2
Structure: contains 1 F-box domain
Pathology:
- defects in FBXO7 are the cause of Parkinson disease type 15
General
F-box only protein
Properties
SIZE: entity length = 522 aa
MW = 59 kD
MOTIF: F-box domain {329-375}
Database Correlations
OMIM correlations
MORBIDMAP 605648
UniProt Q9Y3I1
PFAM correlations
Entrez Gene 25793
Kegg hsa:25793
References
- UniProt :accession Q9Y3I1
- OMIM :accession 605648