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F-box only protein-40 (muscle disease-related protein, FBXO40, FBX40, KIAA1195)

Function: 1) substrate-recognition component of the SCF complex 2) interacts with SKP1A & CUL1 Structure: - contains 1 F-box domain - contains 1 TRAF-type zinc finger Genetics: - SNP in STXBP5L gene & haplotype linkage with another SNP that increases expression of FBXO40 is associated with less photoaging of facial skin [2]

General

F-box only protein zinc finger protein

Properties

SIZE: MW = 80 kD entity length = 709 aa MOTIF: Zinc finger NAME: Zinc finger SITE: 53-112 EFFECTOR-BOUND: Zn+2 F-box domain {570-624}

Database Correlations

UniProt Q9UH90 Pfam PF00646

References

  1. UniProt :accession Q9UH90
  2. Le Clerc S et al. A genome-wide association study in Caucasian women points out a putative role of the STXBP5L gene in facial photoaging. J Invest Dermatol 2013 Apr; 133:929. PMID: 2322314