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familial amyotrophic lateral sclerosis (ALS)

Epidemiology: 5-10% of cases Genetics: 1) defect in SOD1 gene 2) defect in VAPB gene (ALS8) 3) defect in FUS gene (ALS6) 4) defect in ANG gene (ALS9) Laboratory: - ANG gene mutation

Specific

ALS1/familial ALS with SOD1 gene mutation

General

amyotrophic lateral sclerosis (ALS); Lou Gerig's disease genetic disease of the central nervous system

Database Correlations

OMIM correlations

References

  1. Hanby MF et al. The risk to relatives of patients with sporadic amyotrophic lateral sclerosis. Brain 2011 Sep 20 PMID: 21933809 http://neurology.jwatch.org/cgi/content/full/2011/1213/1?q=pfw-featured