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Fas apoptotic inhibitory molecule 2; protein lifeguard 2; neural membrane protein 35; transmembrane BAX inhibitor motif-containing protein 2 (FAIM2 KIAA0950 LFG LFG2 NMP35 TMBIM2)
Function:
- antiapoptotic protein
- protects cells uniquely from Fas-induced apoptosis
- regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation
- may play a role in cerebellar development by affecting cerebellar size, internal granular layer thickness, & Purkinje cell development
- interacts with FAS/TNFRSF6 & BAX
Structure: belongs to the BI1 family, LFG subfamily
Compartment:
- cell membrane; multi-pass membrane protein (putative)
- membrane raft
- cell junction, synapse, postsynaptic cell membrane (putative)
Expression:
- widely expressed
- expressed at high levels in the brain especially in the hippocampus
Pathology:
- highly expressed in breast carcinoma tissues
- enhanced expression correlates with the grade of the tumor in primary breast tumors (at protein level)
- regulated by the AKT1/LEF1 pathway in breast cancer cell lines
Related
apoptosis
CD95; Fas antigen; tumor necrosis factor receptor superfamily member 6; apo-1 antigen; apoptosis-mediating surface antigen FAS; FASLG receptor (FAS, APT1, FAS1, TNFRSF6)
General
glycoprotein
transmembrane 7c protein
Properties
SIZE: MW = 35 kD
entity length = 316 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-105}
MOTIF: serine residue {71-75} (5)
transmembrane domain {106-126}
exoplasmic loop {127-137}
transmembrane domain {138-158}
cytoplasmic loop {127-137}
transmembrane domain {165-185}
exoplasmic loop {186-193}
MOTIF: N-glycosylation site {N191}
transmembrane domain {194-214}
cytoplasmic loop {215-224}
transmembrane domain {225-245}
exoplasmic loop {246-249}
transmembrane domain {250-270}
cytoplasmic loop {271-289}
transmembrane domain {290-310}
exoplasmic domain {310-316}
Database Correlations
OMIM 604306
UniProt Q9BWQ8
Pfam PF01027
Entrez Gene 23017
Kegg hsa:23017
References
UniProt :accession Q9BWQ8