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familial Alzheimer's disease type 5 (FAD5), chromosome 12 associated

Gene locus not well defined (12p11.23-q13.12). It is noted that the locus of the gene for LRP, a receptor for apo E is within this region (12qq13-14). The gene for alpha-2 macroglobulin (a ligand of LRP) is also within this region.

Interactions

disease interactions

General

familial Alzheimer's disease (FAD)

Database Correlations

OMIM 602096 Entrez Gene 8081

References

  1. OMIM :accession 602096
  2. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: 11274343