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coagulation factor Xa inhibitor
Indications:
- prophylaxis for venous thromboembolism after joint replacement (total knee arthroplasty)
- treatment of deep vein thrombosis, venous thromboembolism, pulmonary embolism
Dosage:
- oral agents
Adverse effects:
- hemorrhage
- reversal of activity demonstrated in rats [2]
Bleeding: andexanet reverses factor Xa inhibition
Interactions
drug interactions
drug adverse effects of antithrombotic agent(s)
Related
coagulation factor Xa
Specific
apixaban (Eliquis)
betrixaban (Bevyxxa)
edoxaban (Savaysa)
rivaroxaban (Xarelto)
General
enzyme inhibitor
pharmaceutical anticoagulant
References
- Journal Watch Oncology and Hematology June 5, 2012
Preventing Venous Thromboembolism After Joint Replacement
Massachusetts Medical Society
http://www.jwatch.org (Subsscription required
- Lu G et al.
A specific antidote for reversal of anticoagulation by direct
and indirect inhibitors of coagulation factor Xa.
Nat Med 2013 Apr; 19:446
PMID: 23455714
- Ansell J.
Blocking bleeding: Reversing anticoagulant therapy.
Nat Med 2013 Apr; 19:402
PMID: 23558624
http://www.nature.com/nm/journal/v19/n4/full/nm.3157.html