coagulation factor VIIa

Function: - vitamin K-dependent serine protease - proteolytically activates factor IX & factor X - in the presence of tissue factor & Ca⁺², factor VIIa then converts factor X to factor Xa by limited proteolysis - factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor & Ca⁺² - selective cleavage of Arg-|-Ile bond in factor X to form factor Xa Pharmacology: - recombinant factor VIIa available under the names Niastase or Novoseven (Novo Nordisk) - used for the treatment of bleeding episodes in hemophilia A or hemophilia B patients with antibodies to coagulation factor VIII or factor IX

Related

coagulation cascade coagulation factor VII autoantibody coagulation factor VII; proconvertin; serum prothrombin conversion accelerator; SPCA; Eptacog alfa; contains: factor VII light chain; factor VII heavy chain (F7)

Specific

Factor Viia Parenteral recombinant coagulation factor VIIa (Novo-Seven, rFVIIa, Niastase, Novo, Nordisk)

General

coagulation factor serine protease trypsin family

Properties

COMPARTMENT: plasma STATE: active state MOTIF: charge relay system MOTIF: aspartate residue histidine residue serine residue