thrombin; coagulation factor IIa

Function: - vitamin K-dependent serine protease form by proteolysis of prothrombin - functions in blood homeostasis, inflammation & wound healing - proteolytically activates a) fibrinogen to fibrin b) factor V to factor Va c) factor VIII to factor VIIIa d) factor XIII to factor XIIIa e) in complex with thrombomodulin, protein C f) platelet factor IIa - selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin & release fibrinopeptide A & fibrinopeptide B

Related

coagulation cascade proteinase-activated receptor 3; PAR-3; thrombin receptor-like 2; coagulation factor II receptor-like 2 (F2RL2, PAR3) prothrombin; coagulation factor II; contains: activation peptide fragment 1; activation peptide fragment 2; thrombin light chain; thrombin heavy chain (F2) thrombin receptor; proteinase-activated receptor 1; PAR-1; coagulation factor 2 receptor (F2R, CF2R, PAR1, TR) thrombin/thromboplastin (Thrombinar)

Specific

Thrombin Nasal thrombin topical (Recothrom)

General

coagulation factor multisubunit protein serine protease trypsin family

Properties

SIZE: entity length = 308 aa COMPARTMENT: plasma STATE: active state SUBUNITS: protein subunit MOTIF: disulfide bridge protein subunit MOTIF: disulfide bridge allosteric site FOR-BINDING-OF: antithrombin-III allosteric site FOR-BINDING-OF: thrombomodulin active site

Component-of

calcium chloride/fibrinogen/fibrinolytic inhibitor/thrombin fibrinogen concentrate/thrombin; fibrin sealant (Raplixa) fibrinogen/thrombin molecular complex thrombin/thromboplastin (Thrombinar)