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fatty acid-binding protein-5, psoriasis-associated fatty acid-binding protein homolog
Function:
- lipid transport protein
- high specificity for fatty acids (stearate)
- highest affinity for C18 chain length
- decreasing chain length or introducing double bonds reduces the affinity
- may be involved in keratinocyte differentiation
Structure:
- forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
- belongs to the calycin superfamily, fatty-acid binding protein (FABP) family
Compartment: cytoplasm
Expression:
- keratinocytes
Pathology: highly expressed in psoriatic skin
General
fatty acid/retinol binding protein family
Properties
SIZE: entity length = 135 aa
MW = 15 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
binding site
SITE: 109-109
FOR-BINDING-OF: Fatty acid
cysteine residue {C120}
MODIFICATION: cysteine residue {C127}
cysteine residue {C127}
MODIFICATION: cysteine residue {C120}
Fatty acid binding {129-131}
MOTIF: Tyr phosphorylation site {Y131}
Database Correlations
OMIM 605168
UniProt Q01469
Pfam PF00061
LOCUS-LINK correlations
KEGG correlations
References
UniProt :accession Q01469