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F-box only protein 11; vitiligo-associated protein 1; VIT-1 (FBXO11, FBX11, VIT1, UG063H01)
Function:
- substrate recognition component of the SCF complex
- probably recognizes & binds to phosphorylated target proteins
- binds to & neddylates phosphorylated TP53/p53, inhibiting its transcriptional activity
- SCF(FBXO11) does not seem to direct ubiquitination of TP53
- interacts with TP53
Structure:
- contains 1 F-box domain
- contains 19 PbH1 repeats
- contains 1 UBR-type Zn+2 finger
Compartment: nucleus
Alternative splicing: named isoforms=5
Expression:
- isoform 5 is expressed in keratinocytes, fibroblasts & melanocytes
General
F-box only protein
zinc finger protein
Properties
SIZE: entity length = 927 aa
MW = 104 kD
COMPARTMENT: cell nucleus
MOTIF: F-box domain {153-199}
PbH1 {395-417}
PbH1 {418-440}
PbH1 {441-463}
PbH1 {464-486}
PbH1 {487-509}
PbH1 {510-532}
PbH1 {533-555}
PbH1 {556-578}
PbH1 {579-601}
PbH1 {602-624}
PbH1 {625-647}
PbH1 {648-670}
PbH1 {671-693}
PbH1 {694-716}
PbH1 {717-739}
PbH1 {740-762}
PbH1 {763-785}
PbH1 {786-808}
PbH1 {809-830}
Zinc finger
NAME: Zinc finger
SITE: 833-904
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 607871
UniProt Q86XK2
PFAM correlations
Entrez Gene 80204
Kegg hsa:80204
References
UniProt :accession PS50181