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junctional adhesion molecule A; JAM-A; junctional adhesion molecule 1; JAM-1; platelet F11 receptor; platelet adhesion molecule 1; PAM-1; CD321 (F11R, JAM1, JCAM, UNQ264/PRO301)
Function:
- seems to plays a role in epithelial tight junction formation
- appears early in primordial forms of cell junctions & recruits PARD3
- association of the PARD6-PARD3 complex may prevent interaction of PARD3 with JAM1, thereby preventing tight junction assembly
- role in regulating monocyte transmigration involved in integrity of epithelial barrier
- role in platelet activation
- interacts with the ninth PDZ domain of MPDZ
- interacts with the first PDZ domain of PARD3;
- association of PARD3 & PARD6B probably disrupts this interaction
Structure:
- N-glycosylated
- belongs to the immunoglobulin superfamily
- contains 2 Ig-like V-type domains
Compartment:
- cell junction, tight junction
- cell membrane; single-pass type 1 membrane protein
- localized at tight junctions of both epithelial cells & endothelial cells
Pathology:
- receptor for orthoreovirus
- interacts with the orthoreovirus sigma-1 capsid protein (putative)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
junctional adhesion molecule
phosphoprotein
Properties
SIZE: entity length = 299 aa
MW = 33 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-27}
immunoglobulin superfamily domain {28-125}
MOTIF: cysteine residue {C50}
MODIFICATION: cysteine residue {C109}
cysteine residue {C109}
MODIFICATION: cysteine residue {C50}
immunoglobulin superfamily domain {135-228}
MOTIF: cysteine residue {C153}
MODIFICATION: cysteine residue {C212}
N-glycosylation site {N185}
N-glycosylation site {N191}
cysteine residue {C212}
MODIFICATION: cysteine residue {C153}
transmembrane domain {239-259}
Thr phosphorylation site {T273}
Ser phosphorylation site {S275}
Tyr phosphorylation site {Y280}
Ser phosphorylation site {S281}
Ser phosphorylation site {S284}
Ser phosphorylation site {S287}
Ser phosphorylation site {S296}
Database Correlations
OMIM 605721
UniProt Q9Y624
PFAM correlations
Entrez Gene 50848
Kegg hsa:50848
References
UniProt :accession Q9Y624